Microsoft Natural Wireless Laser Mouse 6000 is for right-handers only. The rear thumb button is not ideally placed, requiring you to move your hand to operate it. As far as surfaces are concerned, the Natural Wireless Laser Mouse 6000 doesn’t get along with cloth pads as the narrower base can dig into the soft surface, but on hard plastic or a desk it’s smooth as silk. At £44, it’s not exactly the cheapest rodent around, but avoiding RSI is definitely worth it, and the science behind the Natural 6000’s ergonomics appears sound in theory.

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